Glucose and sodium chloride injection are not recommended for direct oral administration. Oral administration of injection solutions poses problems such as low absorption efficiency, risk of electrolyte imbalance, mucosal irritation, difficulty in dose control, and potential contamination.
1. Low absorption efficiency:
injection enters the bloodstream directly through veins, and oral administration requires absorption through the digestive tract. The absorption rate of glucose and sodium chloride in the intestine is much lower than intravenous administration, making it difficult to quickly correct dehydration or hypoglycemia. The intestinal mucosa has limited absorption capacity for hypertonic solutions, which may lead to water reverse osmosis exacerbating dehydration.
2. Electrolyte imbalance: The concentration of sodium chloride in
injection is 0.9%. After oral administration, it may cause hypernatremia due to rapid absorption of sodium ions, especially for those with renal dysfunction, with a higher risk. Suddenly consuming a large amount of electrolytes can disrupt the acid-base balance in the body, leading to discomfort symptoms such as nausea and headache.
3. Mucosal irritation: The pH value of
injection varies greatly from the oral environment, and direct oral administration may damage the oral and esophageal mucosa. Hyperosmotic solution can stimulate the gastrointestinal mucosa, causing abdominal pain and diarrhea, and long-term exposure may lead to chronic inflammation.
4. Difficulty in dose control:
Intravenous administration can accurately control intake through drip rate, while oral administration is difficult to accurately calculate actual absorption. Self medication at home can easily lead to overdose or insufficiency, affecting treatment effectiveness and even causing complications.
5. Pollution risk: After
is turned on, the injection is susceptible to microbial contamination, which increases the risk of infection when taken orally. Ampoule bottle cutting may produce glass fragments, which may cause gastrointestinal damage if swallowed by mistake. When oral administration is necessary in special circumstances, it should be diluted and taken in small amounts under the guidance of a doctor, and electrolyte levels should be closely monitored. It is recommended to choose specialized oral rehydration salts for daily fluid replacement, as their glucose and electrolyte ratio is more in line with the characteristics of intestinal absorption. Dehydration after exercise can be treated with electrolyte containing sports drinks, and diarrhea patients are recommended to use low-permeability oral rehydration salts according to the World Health Organization standard formula. When severe dehydration symptoms such as oliguria and blurred consciousness occur, immediate medical attention should be sought for intravenous fluid replacement treatment.
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