Beijing Hospital for the Treatment of Meijie Syndrome

The treatment of Meijie syndrome usually requires comprehensive intervention from neurology or ophthalmology hospitals. In Beijing, it is recommended to choose a tertiary hospital specializing in neurology or ophthalmology, or a medical institution with a diagnosis and treatment center for motor disorders. The standardized treatment for Meijie syndrome mainly includes botulinum toxin injection, oral medication regulation, nerve regulation surgery, rehabilitation training, and psychological intervention. Patients need to develop individualized plans under the guidance of doctors based on the type and severity of symptoms.

1. Botulinum toxin injection

Local injection of botulinum toxin type A is the first-line treatment for blepharospasm type Meijie syndrome, which temporarily alleviates abnormal muscle contractions by blocking the release of acetylcholine at the neuromuscular junction. Common medications include injectable botulinum toxin type A, which requires repeated treatment every 3-6 months. Choosing target muscles such as orbicularis oculi and frown muscle as injection sites may result in adverse reactions such as transient eyelid ptosis and blurred vision.

2. Oral medication regulation

Dopamine receptor modulators such as phenylpropanoid hydrochloride can improve symptoms in some patients, while anti anxiety drugs such as lorazepam can help alleviate stress-induced symptom exacerbation. For patients with comorbid depressive symptoms, low-dose drugs such as paroxetine may be effective. Drug treatment should pay attention to dosage titration to avoid side effects such as drowsiness and dry mouth. Long term use requires regular evaluation of liver and kidney function.

3. Neuromodulation surgery

For drug-resistant cases, deep brain electrical stimulation is an optional option, which involves implanting electrodes to stimulate the subthalamic nucleus or the inner part of the globus pallidus to regulate neural circuits. Surgery requires strict evaluation of indications and regular adjustment of stimulation parameters after surgery. Some patients may choose selective peripheral nerve transection, but there is a risk of recurrence.

4. Rehabilitation Training

Facial muscle relaxation training combined with biofeedback therapy can help patients establish self-control, including progressive muscle relaxation, respiratory training, and other methods. Visual training is helpful for patients with reading blepharospasm, and symptoms can be improved through specific eye movement exercises. Training requires long-term persistence and adjustment to daily lifestyle.

5. Psychological Intervention

Cognitive behavioral therapy can correct patients' catastrophic cognition of symptoms and reduce anxiety and depression caused by social avoidance. Supportive psychotherapy helps patients adapt to chronic illness, while group therapy provides a platform for communication among patients. Stress management techniques such as mindfulness meditation can reduce the frequency of symptom onset and improve quality of life. Patients with Meijie syndrome should pay attention to avoiding strong light stimulation and visual fatigue in daily life, and using anti blue light glasses may alleviate eyelid spasms. Maintaining a regular schedule and moderate exercise can help balance neurological function, while yoga and exercise can relieve physical tension. Increase the intake of whole grains and dark green vegetables rich in vitamin B family in diet, and limit caffeine intake. During acute attacks of symptoms, cold compress around the eyes or gentle massage can be tried. Keeping a symptom diary can help doctors adjust treatment plans. Regularly follow up and evaluate changes in the condition, and promptly deal with complications such as dry eye syndrome or cervical compensatory injury.