A high level of alanine aminotransferase is considered severe

When the level of alanine aminotransferase (ALT) exceeds twice the upper limit of normal, usually greater than 80U/L, caution should be exercised, and a sustained level greater than 200U/L may indicate severe liver injury. The degree of ALT elevation is positively correlated with the risk of liver damage, mainly influenced by factors such as viral hepatitis, fatty liver, drug damage, biliary obstruction, and myocardial infarction.

1. Mild elevation: ALT levels between 40-80U/L, which are 1-2 times the upper limit of normal, are considered mild abnormalities and are commonly seen in non-alcoholic fatty liver disease, staying up late, or physiological fluctuations after drinking alcohol. In such cases, it is recommended to improve lifestyle and have a follow-up examination after one month. Most cases can recover on their own.

2. Moderate elevation: When

ALT reaches 2-5 times the normal value of 80-200U/L, pathological factors need to be investigated. Hepatitis B virus infection, drug-induced liver injury, such as acetaminophen excess, are common inducements, which may be accompanied by fatigue and anorexia. It needs to be further diagnosed in combination with hepatitis B in two halves and liver B-ultrasound.

3. Significant elevation:

ALT>200U/L, exceeding the normal value by 5 times, indicates acute liver cell injury, commonly seen in acute viral hepatitis and toxic liver necrosis. The patient may experience jaundice and coagulation dysfunction, and immediate hospitalization is required to monitor indicators such as bilirubin and prothrombin time.

4. Extreme risk:

ALT>1000U/L is a critical value, commonly seen in acute severe hepatitis, ischemic liver injury, or metabolic diseases. These patients are prone to progress to liver failure and require urgent plasma exchange or artificial liver support therapy.

5. Persistent abnormalities:

ALT fluctuates between 60-150U/L for a long time and should be alert to the progression of chronic liver disease. Autoimmune hepatitis and early cirrhosis may present with persistent mild elevation of ALT, and it is recommended to perform liver biopsy to clarify the pathological stage.

found that elevated ALT should be avoided through high-fat diet and alcohol intake, and priority should be given to choosing whole grains and dark vegetables rich in vitamin B. Moderate aerobic exercise such as brisk walking and swimming can help improve liver metabolism, but it is important to avoid exacerbating liver damage with vigorous exercise. It is recommended to recheck the liver function and liver elasticity every 3-6 months, and simultaneously monitor the HBV DNA load in patients with hepatitis B virus infection. Pregnant women with elevated ALT should distinguish special conditions such as intrahepatic cholestasis of pregnancy.