Will taking weight loss pills definitely cause a rebound

After discontinuing weight loss medication, there may be a rebound, but it is not absolute. The risk of rebound is related to factors such as medication type, lifestyle habits, and metabolic adaptation.

1. Differences in Drug Types:

Appetite suppressant weight-loss drugs tend to rebound after discontinuation, while orlistat lipase inhibitors have a relatively lower risk of rebound as they only block fat absorption. The weight loss effect of some drugs containing diuretic components comes from water loss, and weight regain is significant after discontinuation of medication.

2. Metabolic adaptability:

Long term use of weight loss drugs may reduce basal metabolic rate. If calorie intake remains unchanged after discontinuation, the body is more likely to accumulate fat due to slowed metabolism. Clinical studies have shown that individuals who have been using central nervous system inhibitors for more than 6 months experience an average decrease in basal metabolism of 8% -12% after discontinuing the medication.

3. Behavioral habit influence:

For those who have not established healthy eating and exercise habits during drug dependence, returning to their original lifestyle after stopping the medication will inevitably lead to a rebound. According to data from the American Obesity Association, those who use medication alone without changing their lifestyle have a rebound probability of over 80% within 2 years.

4. Individual differences:

Metabolic disorders such as insulin resistance and polycystic ovary syndrome patients are more likely to rebound. Genetic testing has found that carriers of FTO gene mutations have a 30% -40% reduction in the duration of effectiveness of weight loss drugs compared to the general population.

5. Discontinuation method related:

Central type weight loss drugs for sudden arrest may cause overeating, and gradually reducing the dosage in combination with dietary transition can reduce the risk. It is recommended to perform cognitive-behavioral therapy simultaneously during medication, which can effectively reduce the rebound amplitude by 47% after 6 months of discontinuation.

It is recommended to adjust the dietary structure synchronously during medication, adopt a low glycemic index diet, and ensure a daily protein intake of 1.2-1.6g/kg body weight. Gradually increase resistance training to improve muscle mass. Continue to maintain moderate intensity exercise for 150 minutes per week after discontinuing medication, and regularly monitor changes in body fat percentage. If there is a weight gain exceeding 10% of the original weight loss for two consecutive weeks, it is necessary to consult a nutritionist in a timely manner to adjust the intervention plan. Establishing long-term weight management awareness is more important than relying on medication, and the World Health Organization recommends a safe weight loss rate of 2-4 kilograms per month.