Consuming fewer calories than burning calories usually leads to weight loss. When the human body is in a long-term state of calorie deficit, it will supplement the energy gap by breaking down fat and muscle tissue, thereby achieving weight loss effects. When calorie intake is lower than demand, the body will prioritize using stored glycogen for energy supply. After the depletion of glycogen reserves, triglycerides in adipose tissue begin to hydrolyze into free fatty acids for energy supply, which reduces the volume of adipocytes. At the same time, proteins may also be broken down into amino acids to participate in gluconeogenesis, leading to a decrease in muscle mass. Continuous calorie deficit will gradually decrease body fat percentage, but may be accompanied by a decrease in basal metabolic rate. In some special cases, the heat gap may not directly lead to weight loss. The metabolic rate of patients with endocrine diseases such as hypothyroidism is significantly reduced, and the effect of simply controlling calories is limited. Long term dieting may trigger protective metabolic adaptation, putting the body into energy-saving mode. Some drugs, such as glucocorticoids, can promote water and sodium retention, which may mask the weight change caused by fat loss.
Health weight loss advice: Control the daily calorie deficit within a reasonable range and avoid extreme dieting. A high protein diet combined with resistance training can be adopted to reduce muscle loss, and the weekly weight loss rate should not be too fast. At the same time, it is necessary to ensure the intake of micronutrients such as vitamins and minerals, and regularly monitor changes in body composition. If there are metabolic diseases or abnormal weight fluctuations, timely medical evaluation should be sought.
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