Symptoms such as thirst, palpitations, and insomnia may occur after taking weight loss pills, which may be related to the stimulation of the nervous system, accelerated metabolism, or diuretic effects of the drug ingredients. The common reasons include drugs containing stimulants such as caffeine, diuretics causing dehydration, sympathetic nervous system overexcitement, individual metabolic differences, and adverse drug reactions. Suggest stopping medication immediately and seeking medical evaluation.

1. Caffeine and other stimulants
Some weight loss drugs add central nervous system stimulants such as caffeine and ephedrine to stimulate the sympathetic nervous system and increase metabolic rate. These ingredients can directly cause an increase in heart rate and blood pressure, leading to palpitations and palpitations. Simultaneously stimulating the cerebral cortex can disrupt sleep rhythms, leading to difficulty falling asleep or shallow sleep. Commonly found in illegally added weight loss products, be wary of the three no products.
2. Diuretic ingredients cause dehydration
Some weight loss drugs contain diuretics such as hydrochlorothiazide, which reduce body water by increasing urination. Short term weight loss is actually water loss, which may cause obvious thirst and dry mouth and tongue. Severe dehydration accompanied by electrolyte imbalance can exacerbate symptoms of palpitations. Long term use may damage kidney function, and self medication containing diuretics should be avoided.
3. Excessive excitation of sympathetic nervous system
Some weight loss drugs work by inhibiting the appetite center or promoting fat breakdown, but indirectly activate the sympathetic nervous system. It is characterized by continuous heart rate increase, palmar sweating, restlessness and other reactions similar to anxiety. The parasympathetic nervous system cannot be activated normally at night, resulting in difficulty falling asleep or frequent awakenings at night.

4. Individual metabolic differences
Liver CYP450 enzyme gene polymorphism may lead to differences in drug metabolism rates. People with slow metabolism are more prone to drug accumulation, resulting in significant side effects even at regular doses. Some people are sensitive to components of the sympathetic nervous system, and even low doses can induce reactions such as tachycardia and insomnia. This type of constitution should avoid using stimulating weight loss drugs.
5. Adverse drug reactions
Legitimate weight loss drugs such as orlistat may cause neurological reactions such as headaches and anxiety. Illegal addition of prohibited ingredients such as sibutramine and fenfluramine can lead to severe palpitations, insomnia, and even cardiovascular risks. If accompanied by chest pain and difficulty breathing, immediate emergency treatment is required. It is recommended to purchase drugs through legitimate channels and keep the packaging for doctors to verify the ingredients. When the above symptoms occur, the weight loss medication should be stopped immediately, and an appropriate amount of electrolyte drinks should be supplemented to alleviate dehydration. Record the time of symptom onset and medication dosage, and bring the medication packaging for the doctor's reference during the visit. Long term weight loss is recommended to be achieved through dietary adjustments and exercise, with a daily water intake of at least 2000 milliliters, and avoiding consuming stimulating foods before bedtime. If palpitations and insomnia persist for more than 48 hours, it is necessary to seek medical attention from a cardiology or neurology department to rule out organic diseases.

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