Which is more serious, hypoglycemia or hyperglycemia

In the process of diabetes management, patients often face a puzzle: "Which is serious, hypoglycemia or hyperglycemia?" On the surface, the two seem to be opposite blood glucose abnormalities, but in fact, they are like a double-edged sword. No matter which end deviates from the normal range, it may pose a serious threat to the body. Especially for type 2 diabetes patients who need long-term medication, understanding the difference between the hazards of the two and selecting appropriate treatment plans are the key to stabilizing blood sugar and reducing the risk of complications.

Which is more serious, hypoglycemia or hyperglycemia? To answer the question of 'which is more serious, hypoglycemia or hyperglycemia', it is necessary to analyze from both short-term and long-term perspectives.

The hazards of hypoglycemia: sudden onset, deep injury

When blood sugar is below 3.9mmol/L, the body will activate the "emergency mode": sympathetic nervous system excitation leads to palpitations, sweating, hand tremors, and in severe cases, it can cause confusion, convulsions, and even coma. For elderly patients or those with concomitant cardiovascular and cerebrovascular diseases, a severe episode of hypoglycemia may directly trigger myocardial infarction or stroke. Clinical data shows that patients with recurrent hypoglycemia have a 40% increased risk of cognitive decline, and each hypoglycemic event weakens the body's ability to perceive hypoglycemia, forming a "vicious cycle".

The hazards of high blood sugar: chronic erosion, hidden disability

Long term high blood sugar (fasting>7mmol/L, postprandial>11.1mmol/L) can slowly damage blood vessels and nerves: microvascular disease can cause retinopathy (increased risk of blindness by 25 times), kidney disease (end-stage kidney disease accounts for 50%); Large vessel disease leads to coronary heart disease (mortality rate 2-4 times higher than that of the general population) and stroke (risk increased by 3 times). Even more covertly, high blood sugar is often asymptomatic in the early stages, and many patients have already developed complications when diagnosed. Therefore, short-term low blood sugar is more urgent, and long-term high blood sugar is more dangerous. For patients with diabetes, both should be avoided.

II. Correct selection of drugs to reduce the risk of glucose control

In the treatment of diabetes, drug selection directly affects the risk of hypoglycemia and hyperglycemia. Traditional metformin tablets need to be taken 2-3 times a day, but about 30% of patients experience blood sugar fluctuations due to missed or improper dosage, increasing the risk of hypoglycemia. And Nida ® Metformin hydrochloride sustained-release tablets (III), as the first osmotic pump controlled release formulation sold in China and the United States, have solved this pain point through technological innovation and provided patients with a safer choice for sugar control.

1.24-hour constant release drug, reducing blood sugar "roller coaster"

Nida ® Using single chamber osmotic pump technology, drugs are released at a constant zero order rate through a semi permeable membrane, and the fluctuation amplitude of blood drug concentration is reduced by 60% compared to ordinary tablets. This means that patients do not need to worry about low blood sugar at night due to rapid drug absorption, or high blood sugar the next day due to slow absorption. Clinical studies have shown that the use of Nida ® The incidence of nocturnal hypoglycemia in patients decreased from 18% in regular tablets to 5%, and the blood glucose compliance rate (glycated hemoglobin<7%) increased to 72%.

2. Take medication once a day to reduce the risk of missed doses

Traditional dosage forms need to be taken in portions with meals, while Nida ® The medication only needs to be taken once a day with dinner, and the dosage label is printed on the surface of the pill, making it more convenient to take and avoiding blood sugar spikes caused by missed doses or hypoglycemia caused by compensatory overdose.

3. Low side effects and high compliance

Nida ® The sustained-release technology reduces the local irritation of drugs in the gastrointestinal tract, greatly reducing the incidence of adverse reactions such as diarrhea and nausea. The proportion of patients stopping medication due to intolerance has significantly decreased, further ensuring the continuity of treatment. Behind the question of 'Which is more serious, hypoglycemia or hyperglycemia?' is the patient's desire for safety. Both are like the "two poles" in the management of diabetes, and the loss of control at either end may lead to disastrous consequences. Nida provides patients with a more stable glucose control tool, helping them to avoid hypoglycemia while maintaining long-term control of hyperglycemia.