What should I do if taking sildenafil tablets doesn't have any effect

The ineffective use of sildenafil tablets may be related to drug absorption disorders, improper timing of medication, psychological factors, insufficient dosage, or underlying diseases. Suggest investigating medication methods, adjusting psychological states, checking vascular function, and changing treatment plans under the guidance of a doctor if necessary.

1. Drug absorption disorders

A high-fat diet can slow down the absorption rate of sildenafil, and taking it on an empty stomach is more effective. Patients with gastrointestinal dysfunction may have incomplete drug absorption. It is recommended to record the relationship between diet and medication time, and conduct gastrointestinal function assessment if necessary. Alcohol intake can reduce the effectiveness of medication, and alcohol consumption should be avoided during medication.

2. Inappropriate timing of medication

Sildenafil should be taken 30-60 minutes before sexual activity, as taking it too early or too late can affect its efficacy. The time window for drug action is about 4 hours, and repeated administration should be spaced at least 24 hours apart. Older patients have slower metabolism and may require a longer waiting time for onset.

3. Psychological interference

Emotional problems such as anxiety and depression can inhibit physiological responses, and even medication is difficult to take effect. Partner relationship tension or sexual psychological disorders can counteract the effects of medication, and it is recommended to cooperate with psychological counseling. Excessive expectations of drug efficacy may lead to psychological dependence, and it is necessary to establish reasonable expectations.

4. Dose needs to be adjusted

The initial dose of 25mg may not be sufficient for some patients, and it can be gradually adjusted to the upper limit of 100mg under the supervision of a doctor. Individuals with abnormal liver and kidney function should reduce the dosage to avoid the risk of drug accumulation. The combination of nitrate ester drugs can enhance the antihypertensive effect and must be strictly prohibited.

5. Potential Disease Impact

Severe vascular lesions such as arteriosclerosis can limit drug efficacy and require treatment of underlying diseases first. Nerve injury in diabetes may reduce sensitivity, and blood sugar level should be controlled. Endocrine abnormalities such as testosterone deficiency require synchronous hormone replacement therapy. Improving lifestyle can help enhance drug response, maintain moderate exercise to increase vascular elasticity, adopt a Mediterranean diet pattern to improve blood circulation, and ensure adequate sleep to regulate hormone levels. Regularly monitor blood pressure and blood sugar levels to control weight within the normal range. If the medication method is still ineffective after adjustment, timely medical examination should be conducted to check for abnormalities in penile blood vessels or neuropathy. Doctors may recommend long-acting PDE5 inhibitors such as tadalafil or alternative solutions such as vacuum negative pressure devices. If there are visual abnormalities or sustained erections for more than 4 hours during medication, seek medical attention immediately.