What is the weight loss effect of Orlistat

Orlistat, as a weight loss adjuvant drug, is suitable for obese individuals with a body mass index exceeding 24 and should be used for a short period of time under the guidance of a doctor. The effect varies from person to person, usually combined with dietary control to reduce some fat absorption, but side effects such as gastrointestinal discomfort may occur. Orlistat can reduce fat intake by an average of 30% by inhibiting gastrointestinal lipase activity and blocking the breakdown and absorption of some fats in the diet. Clinical data shows that regular medication for 6 months can cause weight loss of 5-10% in overweight individuals, but individual differences are significant. This medicine has a more significant effect on high-fat diet patients, and it needs to be combined with a low calorie diet to achieve the best effect. Common adverse reactions include oily spots, increased gastrointestinal exhaust, and a sense of urgency in bowel movements, which are often related to uncontrolled fat intake. Long term use may affect the absorption of fat soluble vitamins, and attention should be paid to supplementing vitamins A, D, E, and K. The poor efficacy of SEP in some populations may be related to genetic metabolic differences, such as lipase gene polymorphism affecting drug sensitivity. When metabolic diseases such as hypothyroidism and polycystic ovary syndrome are combined, the effect of using orlistat alone is limited. A small number of patients may be at risk of severe liver damage, manifested as jaundice, darkened urine color, and other symptoms that require immediate discontinuation of medication. Pregnant women, patients with chronic malabsorption syndrome, and cholestasis are prohibited from using it.

It is recommended to develop a personalized plan after evaluation by a professional physician, maintain a daily fat intake of less than 60 grams during medication, and regularly monitor liver function and nutritional status. Weight loss should be based on lifestyle interventions, establishing a reasonable dietary structure and exercise habits, and avoiding dependence on medication. If there is persistent abdominal pain or abnormal bowel movements, seek medical attention promptly and adjust the treatment plan.