What are the causes of chronic gastritis? The five major factors that can easily trigger chronic gastritis

Xiangsha Yangwei Pill for treating gastritis? The etiology and pathogenesis of chronic gastritis have not been fully elucidated. It may be related to the following factors:

1. Survivor of acute gastritis after acute gastritis. Gastric mucosal lesions persist or recur. Both can lead to chronic gastritis.

II. Stimulating food is a diet and medication that strongly irritates the gastric mucosa. Like strong tea. liquor. Spicy or salicylate drugs. Or insufficient chewing during eating. Rough food repeatedly damages the gastric mucosa. Or excessive smoking. Nicotinic acid acts directly on the gastric mucosa.

Three. A study on the reflux of duodenal fluid and long-term medication has found that patients with chronic gastritis suffer from dysfunction of the pyloric sphincter. Often causes bile reflux. It may be an important pathogenic factor. Phospholipids in pancreatic juice work together with bile and pancreatic digestive enzymes. Can dissolve mucus. And destroy the gastric mucosal barrier. Promote the diffusion of H+and pepsin into the mucosa. Further causing damage. The chronic gastritis caused by this mainly occurs in the antrum of the stomach. Gastritis caused by bile reflux is very common in patients undergoing gastrojejunostomy. Patients with peptic ulcers are almost always accompanied by chronic gastritis. It may be related to dysfunction of the pyloric sphincter. Nicotine in tobacco can relax the pyloric sphincter. Long term smokers can promote bile reflux and cause gastritis.

Four. The changes in immune function caused by immune factors have been widely recognized in the pathogenesis of chronic gastritis. Atrophic gastritis. Especially the blood of patients with gastritis. Antibodies against parietal cells can be found in gastric juice or within atrophic mucosa; Internal factor antibodies were found in the blood of patients with gastric atrophy and pernicious anemia. Autoimmune response may be a related cause of certain chronic gastritis. Is there any immune factor involved in the pathogenesis of gastritis. There is no consensus yet. In addition. The gastric mucosa of atrophic gastritis has diffuse lymphocyte infiltration. Abnormal in vitro lymphocyte transformation test and leukocyte migration inhibition test. The cellular immune response may play an important role in the occurrence of atrophic gastritis. Some autoimmune diseases such as chronic thyroiditis.Hypothyroidism or hyperthyroidism. Insulin dependent diabetes. Chronic adrenal insufficiency and other conditions can be accompanied by chronic gastritis. This disease may be related to immune response.

Five. In 1983, Warren and Marshall discovered that patients with chronic gastritis had a large amount of Helicobacter pylori present near the surface of epithelial cells in the mucous layer of the gastric antrum. Its positivity rate is as high as 50-80%. There are reports that this bacterium is not found in normal gastric mucosa. Wherever the bacterium settles, infiltration of gastric mucosal inflammatory cells is observed. And the degree of inflammation is positively correlated with the number of bacteria. Electron microscopy also showed a decrease or dullness in the number of micro protrusions on the surface of epithelial cells connected to bacteria. Anti Helicobacter antibodies can also be found in the patient's blood and gastric mucosa. After treatment with antibiotics. Symptoms and histological changes can improve or even disappear. Therefore, it is believed that. This bacterium may be involved in the onset of chronic gastritis. But it is currently difficult to be certain.