Methods and contraindications for taking sildenafil

Sildenafil is a prescription medication for treating male erectile dysfunction, and strict adherence to medical advice is required before use. The main contraindications include allergies to drug ingredients, taking nitrate drugs, and patients with severe cardiovascular disease. The correct medication method needs to be adjusted according to individual circumstances, and common influencing factors include medication dosage, medication time, dietary coordination, etc.

I. Dosage

Sildenafil is usually taken on an empty stomach 30-60 minutes before sexual activity, with a recommended starting dose of 50 milligrams. The duration of the medication is about 4 hours and cannot be repeated within 24 hours. A high-fat diet may delay drug absorption, and it is recommended to avoid taking it with grapefruit juice. For individuals over 65 years old or with impaired liver function, the dosage should start at 25 milligrams. During medication, cooperative stimulation is necessary to achieve therapeutic effects.

II. Main contraindications

Sildenafil is absolutely contraindicated in patients who are currently using nitrate ester drugs to treat angina, as the combination of the two may lead to fatal hypotension. It is contraindicated for individuals with severe cardiovascular disease, recent myocardial infarction or stroke, uncontrolled hypotension or hypertension. Patients with retinitis pigmentosa and anatomical abnormalities of the penis should use it with caution. Those who are allergic to sildenafil or excipients should stop taking the medication immediately.

III. Drug Interactions

The combination of sildenafil and alpha blockers may enhance the antihypertensive effect and should be taken every 4 hours. When taking CYP3A4 strong inhibitors such as erythromycin and ketoconazole, dosage should be reduced. HIV protease inhibitors may significantly increase blood drug concentrations. Entertainment drugs containing nitrates, such as pentyl nitrate, also have compatibility contraindications.

IV. Adverse Reactions

Common adverse reactions include mild symptoms such as headache, facial flushing, and indigestion. Occasional visual abnormalities such as color vision changes and blurred vision. Rare but serious adverse reactions include sudden hearing loss and sustained erection for more than 4 hours. If cardiovascular symptoms such as angina and dizziness occur, seek medical attention immediately.

V. Attention to Special Groups

Cardiovascular disease patients need to undergo exercise stress testing evaluation before medication. Patients with diabetes may need to adjust the dose. Patients with liver and kidney damage should reduce the initial dose. Not recommended for women or children. During medication, avoid drinking alcohol as it may worsen adverse reactions and reduce the effectiveness of the medication. During the use of sildenafil, blood pressure and heart function should be regularly monitored to avoid activities that require concentration, such as driving or operating machinery. Maintaining a healthy lifestyle and controlling basic diseases such as hypertension and diabetes will help improve erectile function. When storing, it should be kept away from light and moisture, and the temperature should not exceed 30 degrees Celsius. If any abnormal symptoms or poor therapeutic effects occur, timely follow-up should be conducted to adjust the treatment plan. Do not increase or decrease the dosage or change the frequency of medication on your own.