Is there really a saying of metabolic damage

Metabolic impairment does exist, usually referring to the phenomenon of abnormal decrease in basal metabolic rate caused by long-term dieting, diseases, or medication. The main influencing factors include endocrine disorders, extreme diet, chronic inflammation, drug side effects, genetic factors, etc.

1. Endocrine disorders

Hypothyroidism, polycystic ovary syndrome, and other diseases can directly interfere with hormone secretion, leading to reduced energy expenditure. These patients may experience symptoms such as chills and weight gain, and need to be diagnosed through blood tests. Treatment should be targeted at the primary disease, such as levothyroxine sodium tablets to regulate thyroid function, combined with a balanced diet and moderate exercise.

2. Extreme diet

Long term extremely low calorie intake can activate the body's survival mechanism, reduce muscle mass and enzyme activity to reduce consumption. People who repeatedly diet and rebound are more likely to experience metabolic adaptation, manifested as difficulty in losing weight even if their intake is reduced. Gradually increasing calories to a reasonable range and ensuring high-quality protein intake can help restore metabolic vitality.

3. Chronic inflammation

Obesity related chronic low-grade inflammation can hinder insulin signaling and affect mitochondrial function. These patients often experience blood sugar fluctuations and fatigue, and need to improve through anti-inflammatory diets, such as increasing intake of foods rich in antioxidants such as deep-sea fish and berries. If necessary, medication such as metformin should be used under the guidance of a doctor.

4. Drug side effects

Some antidepressants, glucocorticoids, etc. may affect metabolism through central nervous system regulation or changes in fat distribution. During the use of such drugs, it is necessary to strengthen metabolic monitoring and avoid a high sodium and high-fat diet. You can consult a doctor to adjust the medication plan or use metabolic improving drugs such as vitamin D supplements in combination.

5. Genetic factors

Congenital factors such as mitochondrial DNA mutations or UCP1 gene mutations may lead to a lower basal metabolic rate. This group of people needs to maintain a lifelong exercise habit, increase muscle mass through strength training, and adopt a small and frequent diet pattern. If necessary, genetic metabolism specialist intervention is needed. Improving metabolic damage requires multidimensional intervention, and it is recommended to engage in aerobic and resistance combined exercise for at least half an hour daily, such as brisk walking combined with squats. Increase the intake of whole grains and lean meat rich in B vitamins, as well as magnesium rich nuts in the diet. Sleep for at least 7 hours and avoid exposure to blue light at night. Regularly monitor body composition and resting metabolic rate, and if necessary, implement a metabolic restart plan under the guidance of a nutritionist. For metabolic problems caused by pathological factors, priority should be given to treating the primary disease.