Is the normal uric acid index over 500 serious

A normal uric acid index of over 500 is considered high, which may indicate hyperuricemia. The severity should be judged based on symptoms and complications. Hyperuricemia may be related to abnormal purine metabolism, decreased renal function, drug effects, and other factors. If left uncontrolled for a long time, it may induce gout or kidney stones. A uric acid level exceeding 420 micromoles per liter is considered hyperuricemia, while a level above 500 is considered significantly elevated. If there are no symptoms of gout such as joint redness, swelling, heat, and pain, it may be in the stage of asymptomatic hyperuricemia, but long-term elevated levels can still damage the kidneys and blood vessels. Reduce the intake of high purine foods such as internal organs and seafood in daily life, drink more than 2000 milliliters of water per day to promote excretion, and avoid vigorous exercise and alcohol consumption. Obese individuals need to gradually lose weight, but extreme low carbohydrate or hunger therapy should not be used. If there is sudden severe pain in the big toe, ankle joint, or other areas, it may have developed into acute gouty arthritis. In addition to dietary control, uric acid lowering drugs such as allopurinol tablets and febuxostat tablets should be used under the guidance of a doctor. During acute attacks, colchicine tablets can be used in combination to alleviate inflammation. When hypertension or diabetes is combined, priority should be given to the control of basic diseases. Some antihypertensive drugs may affect uric acid metabolism, so doctors should adjust the medication plan.

It is recommended to recheck uric acid levels every 3 months, while monitoring urine routine and renal function. Sudden joint swelling and pain or hematuria should be treated immediately. Patients with recurrent gout should undergo dual energy CT or joint ultrasound examination to evaluate the deposition of urate crystals. Long term poor uric acid control may lead to chronic gouty kidney disease, and even require blood purification treatment.