Is Orlistat weight loss medication safe

Orlistat is generally safe to use as a weight loss medication under the guidance of a doctor, but strict adherence to indications and contraindications is required. Orlistat is mainly used for weight management in obese or overweight patients. Common adverse reactions include gastrointestinal discomfort, fat diarrhea, etc. The risk of severe liver injury is rare but requires caution. Orlistat is a gastrointestinal lipase inhibitor that works by blocking dietary fat absorption. Its safety is based on standardized medication and is applicable to adults with a body mass index exceeding 24. During medication, there may be gastrointestinal reactions such as oily spots and a sense of urgency in defecation, which usually alleviate with prolonged medication. This medicine may affect the absorption of fat soluble vitamins. It is recommended to supplement vitamins A, D, E, and K. Clinical monitoring shows that about 1-3% of users may experience liver dysfunction, but the causal relationship is not yet clear. Orlistat is contraindicated for patients with chronic malabsorption syndrome, cholestasis, and pregnant women. Dosage adjustment is required when combined with cyclosporine, anticoagulants, etc. A very small number of cases have reported severe liver damage, manifested as jaundice, darkened urine color, or upper right abdominal pain. In this case, medication should be immediately stopped and medical attention sought. The safety data for long-term use exceeding 2 years is limited, and it is recommended to evaluate the necessity of medication every 3 months. This medicine is not suitable for simple cosmetic weight loss and needs to be combined with dietary control and exercise to achieve optimal results.

During the use of Orlistat, a low-fat diet should be maintained, and daily fat intake should be controlled below 30 grams to reduce adverse reactions. Avoiding consumption with high-fat meals may reduce the effectiveness of the medication. Regularly monitor weight changes and waist circumference. If the weight loss does not reach 5% after 6 months, consider adjusting the treatment plan. Pay attention to changes in bowel habits and tendencies towards skin and mucosal bleeding. If there is persistent diarrhea or allergic reactions, seek medical attention promptly. It is recommended to obtain medication through formal medical institutions and avoid purchasing weight loss products from unknown sources.