Losing weight when blood pressure is high, blood sugar is slightly high, or blood lipids are high is usually effective and helps improve metabolic abnormalities. Weight control is mainly achieved through adjusting dietary structure and increasing exercise, which can reduce insulin resistance, lower vascular pressure, and decrease lipid deposition. Overweight or obesity is a common risk factor for hypertension, hyperglycemia, and hyperlipidemia. The excessive accumulation of adipose tissue will lead to the decrease of insulin sensitivity, which will urge the pancreas to secrete more insulin to maintain blood sugar stability, and may develop into diabetes in the long term. The free fatty acids released from visceral fat enter the liver, accelerating the synthesis of low-density lipoprotein while inhibiting the production of high-density lipoprotein. The inflammatory factors secreted by adipocytes may also damage the endothelial function of blood vessels, leading to abnormal blood pressure regulation. Losing weight can directly reduce the impact of these pathological and physiological processes. Research has shown that a weight loss of 5% -10% can significantly improve fasting blood glucose and glycated hemoglobin levels, reduce systolic blood pressure by 5-20 mmHg, and also lead to varying degrees of decrease in low-density lipoprotein cholesterol. For some patients with secondary metabolic abnormalities, the weight loss effect may be limited. If the centripetal obesity of patients with Cushing's syndrome is related to excessive secretion of cortisol, the primary disease needs to be treated first. Patients with polycystic ovary syndrome accompanied by hyperinsulinemia may require combined medication intervention. Some genetic lipid metabolism abnormalities, such as familial hypercholesterolemia, have a weaker regulatory effect of weight management on low-density lipoprotein. This type of situation requires the development of a comprehensive treatment plan under the guidance of a doctor.

It is recommended to adopt a Mediterranean dietary pattern, increase intake of whole grains, deep-sea fish, and nuts, and replace animal oil with olive oil. Perform 150 minutes of moderate intensity aerobic exercise per week, such as brisk walking and swimming, combined with resistance training to increase muscle mass. Regularly monitor blood pressure, blood sugar, and blood lipid indicators to avoid excessive dieting leading to malnutrition. If the expected effect is not achieved through 3-6 months of lifestyle intervention, timely medical evaluation should be sought to determine whether there are other pathological factors.


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