Patients with depression need to combine psychological therapy and scientific weight loss plans under the guidance of a doctor, prioritize stabilizing emotions, and gradually adjust diet and exercise.

1. Priority for psychological assessment
Depressed patients should first be evaluated by a psychiatrist for the stability of their condition. It is not recommended to forcefully lose weight during periods of severe depression, as the disruption of neurotransmitters in the brain may exacerbate the emotional fluctuations caused by dieting. The Hamilton Depression Inventory and other commonly used tools in clinical practice are used to monitor the condition, and it is safer to develop a weight loss plan after the condition stabilizes.
2. Balanced diet
Adopting a Mediterranean dietary pattern to supplement omega-3 fatty acids and vitamin D, foods such as salmon and walnuts can help improve symptoms of depression. Avoid extreme dieting that leads to a decrease in serotonin levels, control the daily calorie deficit at 300-500 calories, and ensure a protein intake of 1.2-1.5 grams per kilogram of body weight to maintain muscle mass.
3. Low intensity exercise
starts with 15 minutes of brisk walking or yoga every day, and the endorphins secreted by the brain during exercise can alleviate depression. Avoiding fatigue caused by intense exercise, water sports have less joint pressure and can relax the body and mind. Monitor emotional changes before and after exercise, and adjust intensity promptly if fatigue occurs.

4. Drug Interactions
Some antidepressants such as mirtazapine may increase appetite, and doctors should be informed of weight loss needs to adjust medication. Selective serotonin reuptake inhibitors may affect metabolism, and the combination of weight loss drugs such as orlistat capsules requires strict monitoring of liver and kidney function. If palpitations or dizziness occur during medication, stop taking the medication immediately and seek medical attention.
5. Behavioral cognitive intervention
improves emotional eating through cognitive-behavioral therapy, records dietary diaries to identify triggering factors. Join group therapy to gain social support and avoid exacerbating depression through isolated weight loss. Mindfulness diet training helps distinguish between physiological hunger and emotional hunger, reducing the probability of binge eating. During the weight loss period, patients with depression need to visit the psychiatry and nutrition departments every month, and regularly check their weight, body fat percentage, and mental health indicators. Avoiding extreme weight loss methods and ensuring 7-8 hours of sleep per day can help regulate leptin levels. Family members should pay attention to the patient's emotional changes, and seek medical attention immediately if there is a tendency towards self harm or anorexia symptoms. It is recommended to choose a fitness coach with experience in mental health management and develop a personalized progressive exercise plan.

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