Metformin used for weight loss requires strict adherence to medical advice and cannot be adjusted in dosage or changed in medication. Metformin is a prescription drug for the treatment of type 2 diabetes. Its weight reduction effect is mainly aimed at diabetes patients with overweight or insulin resistance. It is not recommended for healthy people. The weight loss mechanism of metformin is to inhibit liver glycogen output, increase peripheral tissue sensitivity to insulin, thereby reducing blood sugar and fat synthesis. For patients who meet the indications, doctors will develop personalized plans based on weight, blood sugar levels, and kidney function. Typically, the plan starts with a low dose (such as 500 milligrams once daily) and gradually increases to an effective dose (1500-2000 milligrams per day), taken 2-3 times with meals to reduce gastrointestinal irritation. During medication, regular monitoring of blood sugar, liver and kidney function, and vitamin B12 levels is necessary to avoid taking it with alcohol to prevent lactic acidosis. If severe symptoms such as diarrhea, abdominal pain, or fatigue occur, seek medical attention promptly.

Healthy individuals should prioritize diet control and exercise intervention for weight loss. It is recommended to reduce daily calorie intake by 300-500 calories, increase the proportion of whole grains, vegetables, and high-quality protein, and combine with 150 minutes of moderate intensity aerobic exercise per week. During the use of metformin, diabetes patients still need to adhere to lifestyle management, avoid high sugar and high-fat diet, and regularly return to assess the efficacy and safety.
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