Does metformin sustained-release tablets have weight loss benefits

Metformin sustained-release tablets are usually used to treat type 2 diabetes. They have no direct weight loss effect on simple obesity, but may indirectly reduce some patients' weight by regulating blood glucose metabolism. Metformin sustained-release tablets, as insulin sensitizers, mainly control blood glucose by inhibiting hepatic gluconeogenesis and increasing peripheral tissue sensitivity to insulin. For obese type 2 diabetes patients with insulin resistance, the drug may cause slight weight loss due to the improvement of glucose metabolism, but the reduction is limited and individual differences are large. Its weight loss mechanism has a low correlation with reducing visceral fat accumulation and appetite, and cannot replace dietary and exercise interventions. Healthy people or non diabetes obese people may have gastrointestinal discomfort and other adverse reactions after taking it, but it is difficult to obtain the expected weight loss effect.

Some short-term studies show that after using metformin in overweight diabetes patients for 12-24 weeks, the average weight loss is about 2-5 kg, but there is weight rebound. Adolescent patients with polycystic ovary syndrome may benefit from additional weight loss due to hormone regulation, but medication for this special population must strictly follow medical advice. It is worth noting that weight loss is not listed as an indication in the drug instructions. In clinical trials, about 15% of users experienced gastrointestinal reactions such as diarrhea and nausea, which may be misdiagnosed as weight loss effects.

It is recommended that individuals with weight loss needs manage their weight through lifestyle interventions such as scientifically controlling calorie intake and increasing aerobic exercise. If there is diabetes complicated with obesity, a comprehensive treatment plan should be formulated under the guidance of the doctor. Do not take metformin sustained-release tablets on your own to pursue the effect of weight loss. Regularly monitor liver and kidney function and vitamin B12 levels to avoid adverse reactions caused by long-term medication.