Do you want to lose weight by taking metformin

Metformin is mainly used to treat type 2 diabetes. Although it may have a certain weight loss effect, it is not recommended to use it solely for weight loss. The mechanism of action of metformin mainly includes inhibiting liver glycogen output, improving insulin sensitivity, and reducing intestinal glucose absorption.

1. Inhibit hepatic glycogen output

Metformin inhibits hepatic gluconeogenesis and reduces fasting blood glucose levels by activating the AMPK pathway. Long term use may indirectly reduce fat synthesis due to stable blood sugar levels, but individual differences are significant. It should be noted that this medication may lead to vitamin B12 deficiency and requires regular monitoring.

2. Improving insulin sensitivity

drugs can improve the uptake and utilization of glucose in muscle tissue and reduce hyperinsulinemia. Some insulin resistant patients may experience weight loss, but the effect is not significant in non obese individuals. Common side effects include gastrointestinal discomfort, and it is recommended to take it with meals.

3. Reduce intestinal absorption

Metformin can delay the absorption of carbohydrates in the intestine and lower postprandial blood glucose peak. May generate a slight negative heat balance, but the effect is limited. Be alert to possible adverse reactions such as diarrhea and bloating.

4. Regulating gut microbiota

Research has found that this drug may alter the composition of gut microbiota and promote the production of short chain fatty acids. This mechanism is beneficial for metabolism, but the weight loss effect lacks sufficient evidence. Do not adjust the medication plan on your own.

5. Non indication risk

Healthy individuals may experience serious adverse reactions such as lactic acidosis when using SEP. China has not approved its use for weight loss, and taking medication beyond the instructions carries legal and health risks. Diet and exercise intervention should be the first choice for weight loss.

It is recommended to control weight through a balanced diet and regular exercise, ensuring 30 minutes of aerobic exercise per day. Pay attention to reducing intake of refined carbohydrates, increasing vegetables, fruits, and high-quality protein in the diet. If medication intervention is needed, one should choose regular weight loss drugs under the guidance of an endocrinologist and avoid taking metformin on their own. Weight management requires long-term adherence to a healthy lifestyle, and rapid weight loss may pose health risks.