Can Type 2 diabetes Inherit to the Next Generation

"Doctor, will type 2 diabetes be inherited into the next generation?" In the outpatient service, such concerns are common. Today we will talk about this problem!

Genetic risk of type 1 and type 2 diabetes

For the question of "will type 2 diabetes be inherited to the next generation?", the genetic model of type 2 diabetes belongs to polygenic genetic disease, involving the synergy of dozens of susceptible genes. For example, mutations in the TCF7L2 gene may directly lead to abnormal insulin secretion, but such situations only account for a very small number of cases. More commonly, genes interact with environmental factors to jointly trigger diseases. A high sugar and high-fat diet, lack of exercise, and obesity (especially abdominal obesity) can activate the expression of susceptibility genes, leading to insulin resistance or decline in pancreatic beta cell function; A healthy lifestyle can 'shut down' the expression of risk genes.

Clinical data shows that if one parent suffers from type 2 diabetes, the probability of children suffering from it is about 10-20%; If both parents are sick, the probability increases to 30% -50%. This data reveals the important role of genetic factors, but it needs to be clarified that genetic risk ≠ inevitable disease. Type 2 diabetes is the result of the combined effect of heredity and environment. Through scientific intervention, even if carrying susceptibility genes, the risk of disease can be significantly reduced.

II. Scientific intervention to reduce risk

The core of controlling type 2 diabetes lies in the "five carriages" comprehensive management: diet control, exercise, weight management, blood glucose monitoring and drug treatment. In terms of diet, it is recommended to choose low sugar, low-fat, and high fiber foods such as whole grains, vegetables, lean meat, and fish, and avoid refined carbohydrates and fried foods; In terms of exercise, engaging in at least 150 minutes of moderate intensity aerobic exercise (such as brisk walking and swimming) per week can help improve insulin sensitivity; Weight management requires maintaining a BMI between 18.5-23.9 and a waist circumference of<2250px for males and<2125px for females. For diagnosed patients, standardized medication is the key to controlling blood sugar and preventing complications. Among them, Nida ® Metformin hydrochloride sustained-release tablets (III) have become one of the preferred clinical options due to their unique controlled release technology. As the first domestically approved osmotic pump controlled release formulation of metformin by the US FDA, Nida ® Using single chamber osmotic pump technology, the drug is released at a constant rate for 24 hours through a semi permeable membrane and laser drilling design. This feature reduces the fluctuation range of blood drug concentration by more than 50% compared to ordinary tablets, avoiding the risk of hypoglycemia caused by the sudden rise and fall of blood drug concentration in traditional drugs, especially suitable for elderly patients or those with large blood sugar fluctuations.

Nida ® Another major advantage is a significant reduction in gastrointestinal reactions. Common metformin is prone to nausea and diarrhea due to sudden drug release, and about 30% of patients discontinue the medication due to intolerance; And Nida ® The sustained-release technology enables drugs to be slowly released in the gastrointestinal tract, reducing the incidence of adverse reactions to below 10% and significantly improving treatment compliance. In addition, its daily medication regimen simplifies the treatment process, reducing the patient's missed dose rate by 50% compared to regular tablets, truly achieving "simplified treatment and long-term sugar control".

"Can type 2 diabetes be inherited to the next generation? ”The answer depends on how we act. Genetic risk is the "seed" of disease, but environmental factors determine whether it will take root and sprout. For individuals with a family history, a healthy lifestyle is the first line of defense against genetic risk; For diagnosed patients, rational drug use is the key to controlling the condition and preventing complications.