Small molecule peptides generally cannot directly remove blemishes, but may indirectly assist in reducing pigmentation by improving skin metabolism. The formation of pigmentation is mainly related to factors such as ultraviolet radiation, hormonal changes, and skin inflammation.

Small molecule peptides are short chain amino acid combinations formed after protein breakdown, with relatively small molecular weights that are easily absorbed. Some studies have shown that specific small molecule peptides may inhibit tyrosinase activity and reduce melanin synthesis, such as certain marine fish collagen peptides. These ingredients may be administered orally or topically to the skin to help regulate the moisture content of the stratum corneum, enhance skin barrier function, and thereby reduce UV induced pigmentation. For pigmentation related to skin barrier damage such as melasma, it may have a certain auxiliary improvement effect. However, the mechanism of pigmentation formation is complex, and relying solely on small molecule peptides is difficult to completely eliminate. Freckles are related to genetic factors, while age spots involve lipofuscin deposition, and these types of spots have limited response to small molecule peptides. If sunspots formed after exposure to sunlight are not repaired in a timely manner, pigments may penetrate deep into the dermis layer, requiring more effective medical intervention. Some small molecule peptide products claiming to remove freckles may illegally add prohibited ingredients such as hydroquinone, posing safety risks.

It is recommended that patients with pigmentation prioritize sun protection measures and use skincare products containing compliant whitening ingredients such as vitamin C and arbutin. For stubborn pigmentation, consult a dermatologist and choose medical methods such as laser treatment and chemical exfoliation. Daily intake of foods rich in antioxidants, such as blueberries, tomatoes, etc., can help reduce the damage of oxidative stress to the skin. Maintaining a regular daily routine can also help regulate the endocrine system and prevent the worsening of pigmentation.

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