Orlistat is usually not recommended to be taken when not eating. This medication should be taken with meals or within one hour after meals, mainly to inhibit the absorption of fat in the diet. Taking it on an empty stomach may reduce its efficacy and increase the risk of gastrointestinal discomfort. Orlistat is a lipase inhibitor that works by blocking the breakdown of dietary fat by gastrointestinal lipase, reducing fat absorption by about one-third. If high-fat foods are not consumed, the medication may not have the expected effect and may instead stimulate the gastrointestinal mucosa, causing adverse reactions such as abdominal pain and oily spots. Clinical recommendations suggest that medication should be taken three times a day in sync with regular meals, with better results achieved when the fat content of a single meal exceeds 10 grams. In special circumstances such as accidental or missed ingestion, there is no need to supplement, but it is necessary to avoid doubling the next dose. For light fasting days or liquid diet periods without fat intake, medication should be suspended. Long term consumption on an empty stomach may lead to a deficiency of fat soluble vitamins, and attention should be paid to supplementing nutrients such as vitamin A, D, E, K, etc.
During the use of Orlistat, it is necessary to maintain a balanced diet, avoid high-fat foods that increase intestinal burden, and combine moderate exercise to enhance weight loss effects. If severe diarrhea or allergic reactions occur, seek medical attention promptly. Chronic disease patients should consult a doctor to assess the risk before taking medication. It is recommended to regularly monitor weight changes and nutritional status to avoid adjusting medication plans on one's own.
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