Can normal people lose weight by taking metformin

Normal people who take metformin usually do not achieve weight loss effects, and if taken without medical advice, it may cause adverse reactions. Metformin is a prescription drug for the treatment of type 2 diabetes. Its weight loss effect is related to improving insulin resistance, and its metabolic effect on non diabetes patients is limited.

The weight loss mechanism of metformin is mainly aimed at diabetes patients with insulin resistance. This drug inhibits liver glycogen output, increases peripheral tissue uptake of glucose, and may also mildly suppress appetite. But when insulin function is normal in healthy individuals, these effects are not significant. Clinical observation shows that the weight change of non diabetes population after taking metformin is small, and some people may have 1-2 kg weight loss, but the individual difference is large and the effect is not lasting. The drug instruction clearly indicated that its indication was diabetes treatment, and it was not approved for simple weight loss.

Healthy individuals who take metformin without authorization may face risks such as gastrointestinal discomfort and vitamin B12 deficiency. Common adverse reactions include gastrointestinal symptoms such as diarrhea, nausea, and bloating, and long-term use may affect nutrient absorption. Some patients may experience serious complications such as lactic acidosis, especially those with renal insufficiency who have a higher risk. The Expert Consensus on Clinical Application of Metformin in China emphasizes that the drug must be used under the guidance of a doctor and is prohibited from being used solely for weight loss purposes.

It is recommended to control weight through a balanced diet and regular exercise. Maintain 30 minutes of aerobic exercise daily, such as brisk walking, swimming, etc., combined with reducing refined carbohydrates intake and increasing the proportion of vegetables, fruits, and high-quality protein. If there are abnormal fluctuations in weight or metabolic problems, timely medical evaluation should be sought instead of self medication. Patients with diabetes also need to regularly monitor liver and kidney functions and vitamin B12 levels during the use of metformin.