Can dapoxetine hydrochloride treat premature ejaculation

Dapoxetine hydrochloride can be used to treat premature ejaculation. Premature ejaculation may be related to psychological factors, neurotransmitter disorders, prostatitis, high sensitivity of the glans penis, genetic factors, and other reasons. Dapoxetine hydrochloride is a selective serotonin reuptake inhibitor that prolongs ejaculation latency by regulating neurotransmitter levels. It should be used in a standardized manner under the guidance of a doctor.

1. Drug mechanism of action

Dapoxetine hydrochloride regulates the ejaculation reflex neural pathway by inhibiting neuronal reuptake of serotonin, increasing the concentration of serotonin in synaptic cleft. This drug takes effect quickly, usually reaching the peak blood concentration 1-2 hours after taking it, and is suitable for on-demand use. Clinical data shows that it can significantly prolong the latency period of vaginal ejaculation and improve the quality of sexual life.

2. Target population

This drug is suitable for men aged 18-64 with primary or secondary premature ejaculation, especially for those with ejaculation control disorders caused by an imbalance of serotonin neurotransmitters. For patients with combined depression, caution should be exercised when using antidepressants, and for those with severe liver and kidney dysfunction, the dosage should be adjusted. Organic diseases such as thyroid dysfunction should be ruled out before medication.

3. Usage

It is recommended to take 1-3 hours before sexual activity, and the whole tablet should be swallowed with sufficient water. The initial dose starts from 30mg and can be increased to 60mg based on efficacy and tolerability, with no more than once within 24 hours. Avoid drinking alcohol during medication to prevent worsening of adverse reactions such as dizziness. Continuous use for 4-6 weeks is required to evaluate efficacy, and sudden discontinuation of medication is not recommended.

4. Precautions

Common adverse reactions include nausea, dizziness, insomnia, etc., which are mostly mild and can be relieved on their own. It is prohibited to use it in combination with monoamine oxidase inhibitors, sulfamethoxazole, and other drugs. Patients with moderate to severe heart failure and mania are prohibited from using it. Seek medical attention immediately if fainting or blurred vision occurs during medication. Long term use requires monitoring of emotional changes and liver function.

5. Alternative options

Behavioral therapies such as stop motion and compression can be used as adjuvant therapy. Local anesthetics such as lidocaine gel can reduce the sensitivity of glans penis. Antidepressants such as sertraline and paroxetine need to be taken continuously to be effective. Severe organic premature ejaculation may consider selective dorsal penile nerve transection, but strict evaluation of surgical indications is required. Premature ejaculation patients should maintain a regular frequency of sexual activity and avoid excessive masturbation. Daily Kegel exercises can be performed to enhance pelvic floor muscle control, combined with cognitive-behavioral therapy to improve anxiety. Pay attention to supplementing trace elements such as zinc and magnesium in diet, and limit spicy and stimulating foods. It is recommended that partners participate in the treatment together and establish a harmonious mode of sexual communication. If the symptoms persist and do not improve, it is necessary to go to a urology or urology department for specialized examinations such as neurophysiology.