Why lose weight diabetes good

Weight loss can help to improve diabetes mainly due to the increased insulin sensitivity and enhanced glucose metabolism after weight loss. The effects of weight loss on diabetes mainly include reducing insulin resistance, reducing visceral fat accumulation, improving pancreatic function, reducing chronic inflammation, and adjusting the balance of intestinal flora.

1. Reduce insulin resistance

After weight loss, the volume of adipocytes decreases, which can reduce the release of free fatty acids and enhance the responsiveness of muscles and liver to insulin. Clinical observations have shown that weight loss can improve the activity of glucose transporters in skeletal muscle cells and promote the entry of blood glucose into cellular metabolism. The combination of metformin tablets, acarbose tablets, glimepiride tablets and other drugs has a more significant weight loss effect.

2. Reduce visceral fat accumulation

Abnormal secretion of adipokines by visceral adipose tissue in abdominal obesity can interfere with insulin signaling, and a decrease in intra-abdominal fat content after weight loss can reduce the release of inflammatory factors such as tumor necrosis factor alpha. For every 1 centimeter reduction in waist circumference, fasting blood glucose levels can significantly decrease, which is related to the reduction of hepatic gluconeogenesis after the alleviation of fatty liver.

III. Improving pancreatic function

Obesity induced glucose and lipid toxicity can damage pancreatic beta cells, and moderate weight loss can reduce the sustained stimulation of the pancreas by blood glucose fluctuations. Research has found that the first phase insulin secretion function partially recovers after weight loss, which is related to the reversal of beta cell dedifferentiation. Medications such as regorazine tablets and sitagliptin tablets can be used in conjunction with lifestyle interventions.

Fourth, reduce the level of chronic inflammation

Excessive proliferation of adipose tissue activates macrophages, leading to chronic low-grade inflammation. After weight loss, inflammatory markers such as C-reactive protein levels decrease. This change helps to repair insulin receptor substrate phosphorylation disorders, and subcutaneous fat reduction has a more significant improvement in inflammation than visceral fat reduction.

V. Adjusting the balance of gut microbiota

Obese individuals have an imbalanced ratio of Firmicutes/Bacteroidetes in their gut microbiota, and an increase in short chain fatty acid producing bacteria after weight loss can promote the secretion of glucagon like peptide-1. Increasing dietary fiber intake combined with exercise can maintain microbial diversity, and this change can regulate appetite and glucose metabolism through the gut brain axis.

It is recommended that diabetes patients develop personalized weight loss programs under the guidance of doctors, carry out moderate strength training combined with aerobic exercise every week, increase the proportion of green leafy vegetables and high-quality protein in their diet, and avoid extreme dieting. Regularly monitor blood glucose and glycated hemoglobin, be alert to the occurrence of hypoglycemia during weight loss, and adjust the dosage of hypoglycemic drugs if necessary. Long term maintenance of 5-10% weight loss can bring significant metabolic improvement.