Which is better for the protection effect of the third injection of Sinopharm and Kexing COVID-19? What are the precautions for COVID-19 booster injection

With the launch of COVID-19 vaccine and the national implementation of free vaccination for all, more and more people have been vaccinated with COVID-19 vaccine. So, which is better, the currently listed Beijing Kexing vaccine or the COVID-19 vaccine of Sinopharm? What are the precautions after vaccination?

I. Which is better, Beijing Sinovac or Sinopharm's COVID-19 vaccine? The protective efficacy data released by Sinopharm and Sinovac vaccines both meet the relevant technical standards of the World Health Organization and relevant national technical standards. In terms of safety, no case of obvious side effects occurred in either Kexing COVID-19 vaccine or COVID-19 vaccine.

1. Beijing Kexing Zhongwei COVID-19 Vaccine

Approved on: February 5, 2021

Vaccine type: inactivated vaccine

Vaccine safety: COVID-19 inactivated vaccine of Kexing Zhongwei is called Kelafu. The vaccine entered Phase I and Phase II clinical studies in April 2020, and the safety and effectiveness of the vaccine were confirmed through studies. The Phase III clinical study carried out in Brazil and Türkiye evaluated the protective efficacy of Kelafu in high-risk groups (medical staff receiving patients with COVID-19 pneumonia) and the general population respectively. Both countries adopted a multicenter, randomized, double-blind, placebo parallel control design, and the main endpoint was the incidence rate of COVID-19 induced diseases 14 days after the vaccination of two doses of vaccine or placebo.

Vaccine effectiveness: On February 5, Beijing Kexing Zhongwei Biotechnology Co., Ltd. announced the phase III clinical research data of the novel coronavirus inactivated vaccine Kelafu. The results showed that through the Phase III clinical studies in Brazil and Türkiye, the protective effect of the vaccine against the disease caused by COVID-19 was more than 50%, up to 91.25%.

Inoculation dose: 2 doses

2. Sinopharm Group vaccine

(1) Wuhan COVID-19 vaccine

vaccine was approved on February 25, 2021

vaccine type: inactivated COVID-19 vaccine

vaccine effectiveness: Since July 16, 2020, Wuhan Institute of Biological Products has carried out the "Phase III clinical trial of COVID-19 inactivated vaccine" in many countries, such as the United Arab Emirates. The trial adopts the "international multicenter, randomized, double-blind, placebo parallel control design".

The results of the interim analysis of data in the phase III clinical trial show that the safety of the COVID-19 inactivated vaccine of the Wuhan Institute of Biological Products of China is good after vaccination. After the vaccination of the two immunization procedures, the vaccinators produced high titers of antibodies, and the positive conversion rate of neutralizing antibodies was 99.06%. The protection rate of COVID-19 vaccine against the confirmed moderate and severe cases reached 100%, and the total protection effect was 72.51%, meeting the relevant technical standards of the World Health Organization and the requirements of the relevant standards in the Guiding Principles for Clinical Evaluation of novel coronavirus Vaccines for Prevention (Trial) issued by the State Food and Drug Administration. [SEP]. At least 34 countries worldwide are conducting vaccination or emergency use. More than 10 heads of state and dignitaries have been vaccinated with China's COVID-19 Biological Vaccine.

Vaccine effectiveness: the vaccine is safe after vaccination. After two shots of the immunization program, the vaccinators in the vaccine group all produced high titers of antibodies, and the positive conversion rate of neutralizing antibodies was 99.52%. The protective effect of the vaccine against diseases caused by COVID-19 infection was 79.34%.

Inoculation dose: 2 doses

II. What are the precautions for Beijing Kexing COVID-19 after vaccination?

1. Maintain a light diet: Within one week of vaccination, avoid consuming spicy and stimulating foods, seafood, and alcoholic beverages. Eat a light diet and drink plenty of water.

2. Pay attention to the hygiene of the injection site: those vaccinated with COVID-19 vaccine should avoid water on the injection site and pay attention to local hygiene on the day after vaccination to prevent skin infection.

3. Avoid contact with individuals with known allergies and common allergens (pet hair, dust mites, pollen, etc.).

4. Avoid vigorous exercise.

5. After vaccination, the recipient should be observed for 30 minutes at the vaccination unit. During the observation period, if the recipient experiences symptoms such as pale complexion, sweating, wet and cold limbs, rash, weak pulse, cyanosis, swelling of the face and throat, and difficulty breathing, please immediately seek medical attention from the vaccination site doctor.

To sum up, the effectiveness and safety of COVID-19 vaccine of Beijing Kexing and Sinopharm are reliable, and there is no need to delay vaccination in order to wait for a certain vaccine.