What is the reason for low glycated hemoglobin

Low glycated hemoglobin may be caused by recent episodes of hypoglycemia, anemia, hemolytic diseases, metabolic changes during pregnancy, or abnormal liver function. It can be improved by adjusting dietary structure, treating underlying diseases, and regularly monitoring blood sugar.

1. Hypoglycemic episodes:

Frequent hypoglycemia can lead to a decrease in the binding of glucose and hemoglobin in the blood, resulting in low detection values. It is commonly seen in patients with diabetes after excessive insulin use, prolonged fasting or strenuous exercise. It is necessary to prevent hypoglycemia by eating regularly, adjusting the hypoglycemic plan, and monitoring fingertip blood glucose to assist in judgment.

2. Anemia effects:

Iron deficiency anemia or megaloblastic anemia can shorten the lifespan of red blood cells, leading to a decrease in total hemoglobin. The patient may experience symptoms such as fatigue and dizziness. It is recommended to improve blood routine examination and supplement hematopoietic materials such as iron and folic acid. After the hemoglobin returns to normal, the glycosylated hemoglobin value will gradually increase.

3. Hemolytic diseases:

Hereditary spherocytosis, thalassemia, and other hemolytic diseases can accelerate the destruction of red blood cells, leading to insufficient glycated hemoglobin testing cycles. These patients are usually accompanied by symptoms such as jaundice and splenomegaly, and need to be diagnosed through genetic testing. If necessary, splenectomy or blood transfusion treatment may be performed.

4. Changes during pregnancy:

Increased blood volume in pregnant women can lead to physiological blood dilution, while increased insulin resistance in the middle and late stages of pregnancy may cause reactive hypoglycemia. It is recommended that pregnant women adopt a low glycemic index diet and prioritize low glycemic index foods. Glycated hemoglobin and fasting blood glucose should be rechecked every 4-6 weeks.

5. Abnormal liver function:

Patients with cirrhosis have decreased liver glycogen storage capacity and are prone to postprandial hypoglycemia. Meanwhile, liver function impairment can affect hemoglobin metabolism, and the detected value may be lower than the actual level. It is necessary to combine liver function tests to evaluate and treat the primary disease while appropriately adding bedtime meals.

For individuals with low glycated hemoglobin, it is recommended to consume moderate amounts of complex carbohydrates such as oats and whole wheat bread daily to maintain blood sugar stability and avoid high sugar foods that can cause blood sugar fluctuations. Hemoglobin synthesis requires high-quality protein intake, consuming animal liver and blood products 2-3 times a week. Moderate aerobic exercise can improve insulin sensitivity, but fasting exercise should be avoided. Patients with hemolytic diseases should use oxidative drugs with caution, and anemic patients can supplement with vitamin C to promote absorption during iron supplementation. All abnormal indicators need to be comprehensively judged by professional doctors based on clinical manifestations.