The production process and technical route of COVID-19's third dose and two doses are different

The production process and technical route of COVID-19 vaccine are different.

The principle of COVID-19 inactivated vaccine is to use African green monkey kidney (Vero) cells for virus culture and amplification, inactivate the virus with β - propionolactone, retain antigen components to induce immune response of the body, and add aluminum hydroxide adjuvant to improve immunogenicity.

The principle of recombinant COVID-19 vaccine (CHO cell) is to recombine the receptor binding region (RBD) gene of COVID-19 S protein into the Chinese hamster ovary (CHO cell) gene, express it in vitro to form RBD dimer, and add aluminum hydroxide adjuvant to improve immunogenicity. Its technical principle is similar to that of the mature hepatitis B CHO cell vaccine.

Both vaccines have been approved by the national drug regulatory authorities and have good safety and immune efficacy, both of which can provide good protection. It is suggested that citizens do not need to deliberately wait for a certain vaccine, as long as their physical conditions are met, they can be safely vaccinated.