The efficacy and side effects of metformin sustained-release tablets

Metformin is the cornerstone drug for the treatment of type 2 diabetes. The efficacy and side effects of metformin sustained-release tablets have always been the focus of patients' attention. With the advancement of drug development technology, from regular tablets to sustained-release tablets, and then to third-generation osmotic pump controlled release formulations, the iteration of metformin has not only optimized its sugar control effect, but also made breakthroughs in reducing side effects and improving medication compliance.

1. The efficacy and side effects of metformin sustained-release tablets

1. The efficacy of metformin sustained-release tablets

The core efficacy of metformin sustained-release tablets lies in multi-target regulation of blood glucose metabolism. It reduces liver glucose output by inhibiting hepatic gluconeogenesis, while enhancing peripheral tissue (such as muscle and fat) sensitivity to insulin, promoting glucose uptake and utilization. Clinical research shows that the drug can significantly reduce fasting blood glucose and postprandial blood glucose, reduce the level of glycosylated hemoglobin, and effectively delay the progress of complications of diabetes. In addition to lowering blood sugar, metformin sustained-release tablets also have metabolic regulatory effects. It can reduce triglyceride and low-density lipoprotein cholesterol levels, increase high-density lipoprotein cholesterol, and improve blood lipid abnormalities; By suppressing appetite, increasing fat oxidation and decomposition, helping overweight or obese patients lose weight; Long term use can also reduce the risk of cardiovascular events and improve inflammation and fibrosis in non-alcoholic fatty liver disease.

2. Side effects of metformin sustained-release tablets

Despite significant therapeutic effects, traditional metformin sustained-release tablets still have certain side effects. It needs to be taken 1-2 times a day, and drug release is easily affected by the gastrointestinal environment, leading to fluctuations in blood drug concentration. Common side effects include:

Gastrointestinal reactions: nausea, vomiting, and diarrhea are more common, especially in the early stages of medication, and some patients may stop taking the medication due to intolerance. Low medication adherence: Taking medication multiple times a day can lead to a dropout rate of up to 65%, which affects long-term efficacy.

II. Nida ® (Metformin Hydrochloride Extended Release Tablets (III)): The third-generation Metformin Extended Release Tablets [SEP], as the first osmotic pump controlled release dosage form sold in both China and the United States, are produced by Nida ® 24-hour constant rapid drug release was achieved through single chamber osmotic pump technology. The surface of its tablets is laser drilled, covered with a semi permeable membrane, and the drug is released at a zero order rate using osmotic pressure difference. The fluctuation range of blood drug concentration is reduced by more than 70% compared to ordinary tablets. This innovation brings three major advantages:

1. Once a day, simplified treatment

Nida ® It only needs to be taken once a day with dinner, solving the pain point of frequent medication in traditional dosage forms. Real world research shows that its 6-month continuous treatment rate is 40% higher than that of regular tablets, especially suitable for patients with irregular lifestyles or those who are prone to missed doses.

2. Reduced side effects and significantly improved gastrointestinal tolerance

Constant release drugs reduced local irritation to the gastrointestinal tract, and the incidence of adverse reactions such as nausea and diarrhea decreased by more than 50%. Bioequivalence tests have confirmed that Nida ® The therapeutic effect of a single 2g oral dose and Gehuazhi ® (Regular tablets) 1g twice a day is equivalent, but there are fewer gastrointestinal events.

3. International Quality, Double Certification between China and the United States

Nida ® Certified by the US FDA and China NMPA, the production standards comply with the requirements of co production between China and the United States. Its price is only 60% of the original research drug, and it is included in the national medical insurance basic drug catalog, truly achieving "international quality, affordable price". The above is an introduction to the efficacy and side effects of metformin sustained-release tablets. The efficacy and side effects of metformin sustained-release tablets need to be balanced in individualized treatment. For newly diagnosed patients, those with inadequate blood glucose control, or those who are intolerant to traditional dosage forms, Nida ® With its 24-hour stable glucose control, low side effects, and convenience, it has become an important choice for optimizing treatment plans.