How many injections should be given to the COVID-19 booster needle of Wuhan Biology? Which is better, the third needle of COVID-19 of Wuhan Biology or Anhui Zhifei

Before inoculation of COVID-19 vaccine, everyone will know the vaccine brand first. At present, there are five major enterprises producing COVID-19 vaccine in China, namely Beijing Biotech, Beijing Kexing, Wuhan Biotech, Anhui Zhifei and Tianjin Kangsino. So, how many shots of Wuhan Biological COVID-19 vaccine? Can we mix up with Beijing Kexing? Which is better than Anhui Zhifei?

I. How many shots of Wuhan Biological COVID-19 vaccine?

Wuhan Biological COVID-19 Vaccine is an inactivated vaccine, which requires 2 doses in the whole process. The interval between the first dose and the second dose should be 3 weeks or more, and the second dose should be completed as soon as possible within 8 weeks after the first dose.

II. Can Wuhan Biological COVID-19 Vaccine and Beijing Sinovac be mixed?

1. According to the Technical Guidelines for COVID-19 Vaccination (First Edition), it is recommended to use COVID-19 inactivated vaccine from the same enterprise to complete the whole process of vaccination at this stage. If the vaccine cannot be supplied continuously, the recipient cannot be vaccinated in another place and other special circumstances make it impossible to use the inactivated COVID-19 vaccine of the same enterprise to complete the whole vaccination process, the vaccine products of other manufacturers of the same kind can be used to complete the vaccination.

In the afternoon of May 20, the joint prevention and control mechanism of the State Council held a press conference. Wang Huaqing, chief expert of immunization planning of the Chinese Center for Disease Control and Prevention, introduced that according to the technical guidelines for COVID-19 vaccination, in principle, it is recommended to use the products of the same enterprise with the same technical route to complete two or three dose vaccination procedures. If there are no products from the same enterprise or technology route available for supply, it is recommended to use products from the same technology route as substitutes. That is, inactivated vaccines can only replace inactivated vaccines, protein subunit vaccines can only replace protein subunit vaccines, and adenovirus vaccines can only be administered once, so there is no "mixed vaccination" situation.

In other words, if conditions permit, it is recommended to receive two doses of the same type of vaccine from the same manufacturer. But if the situation does not allow, the same type of vaccine from different manufacturers is also possible. Both inactivated vaccines, the first dose from Wuhan Biotech and the second dose from Beijing Kexing, are not a problem.

III. Which is better, Wuhan Biological COVID-19 Vaccine or Anhui Zhifei Vaccine?

1. The approval time of COVID-19

vaccine: February 25, 2021

vaccine type: inactivated COVID-19 virus vaccine

vaccine effectiveness: From July 16, 2020, the Wuhan Institute of Biological Products carried out the "Phase III clinical trial of COVID-19 inactivated vaccine" in many countries, such as the United Arab Emirates, which adopted the "international multicenter, randomized, double-blind, placebo parallel control design".

The results of the interim analysis of data in the phase III clinical trial show that the safety of the COVID-19 inactivated vaccine of the Wuhan Institute of Biological Products of China is good after vaccination. After the vaccination of the two immunization procedures, the vaccinators produced high titers of antibodies, and the positive conversion rate of neutralizing antibodies was 99.06%. The protection rate of COVID-19 vaccine against the confirmed moderate and severe cases reached 100%, and the total protection effect was 72.51%, meeting the relevant technical standards of the World Health Organization and the requirements of the relevant standards in the Guiding Principles for Clinical Evaluation of novel coronavirus Vaccines for Prevention (Trial) issued by the State Food and Drug Administration.

2. Approval time of Zhifei Biological COVID-19 Vaccine

vaccine: March 10, 2021

Vaccine type: recombinant COVID-19 vaccine

Vaccine effectiveness: according to data, 76% of people can produce neutralizing antibodies after two doses of Zhifei vaccine. 97% of people can produce neutralizing antibodies after receiving three doses of the vaccine. The geometric mean titer (GMT) of the antibody reached 102.5, which exceeded the serum neutralizing antibody level of 89 COVID-19 rehabilitation patients.

Inoculation dose: 3 doses

In general, Wuhan COVID-19 Biological Vaccine belongs to inactivated COVID-19 Vaccine, which requires two doses in total and can be mixed with Beijing Kexingneng.