Does taking metformin have a weight loss effect on obesity

Obese patients taking metformin may have some weight loss effects, but it is not a medication specifically designed for weight loss. Metformin is mainly used to treat type 2 diabetes. The effect of weight loss varies from person to person. It is recommended to use it under the guidance of doctors. Metformin lowers blood sugar by improving insulin resistance, inhibiting liver gluconeogenesis, and reducing intestinal glucose absorption. Some obese patients may experience weight loss after use, which is related to drugs that reduce appetite and improve metabolism. But the degree of weight loss is relatively mild, usually a few percent of the initial weight, and the effect may weaken with prolonged medication time. For non diabetes patients, the weight loss effect of metformin lacks sufficient evidence to support. In rare cases, metformin may cause gastrointestinal discomfort such as nausea, diarrhea, and other side effects, which can actually affect nutrient absorption. Patients with severe liver and kidney dysfunction, alcohol abuse, and hypoxia should not use this medication. The use of metformin solely for weight loss purposes may bring unnecessary medication risks, such as vitamin B12 deficiency, lactic acidosis, etc. Obesity management should prioritize lifestyle interventions such as diet control and exercise. If insulin resistance or pre diabetes exists, doctors may consider using metformin at their discretion. During medication, regular monitoring of blood glucose, liver and kidney function, and other indicators is necessary to avoid self adjustment of dosage. It is recommended to develop personalized weight loss plans based on the guidance of nutritionists, rather than relying on a single medication.