At present, there are no absolutely safe and effective weight loss drugs. Weight loss should be based on diet control and exercise, and if necessary, medication such as orlistat capsules and sustained-release capsules of fentanyl hydrochloride should be used under the guidance of a doctor for adjuvant treatment. Orlistat capsules are a gastrointestinal lipase inhibitor that achieves weight loss by reducing dietary fat absorption. They are suitable for obese patients with a body mass index exceeding 28. Common adverse reactions include oily spots, increased gastrointestinal exhaust, etc. Long term use may affect the absorption of fat soluble vitamins. The sustained-release capsule of pheniramine hydrochloride exerts its effect by inhibiting the appetite center and is suitable for obesity with ineffective dietary and exercise control. It may cause side effects such as dry mouth and constipation, and is contraindicated for patients with cardiovascular disease. Liraglutide injection, as a GLP-1 receptor agonist, can delay gastric emptying and increase satiety, but requires subcutaneous injection for use. Chlorhexidine was once used to suppress appetite, but has been delisted due to potential carcinogenic risks. Although metformin can improve insulin resistance, it has limited effect on weight loss in non diabetes patients.

Weight loss pills all have varying degrees of side effects and cannot be purchased or used on their own. It is recommended to scientifically lose weight by adjusting dietary structure, controlling daily calorie intake, and increasing aerobic exercise. Overweight individuals should regularly monitor their weight, waist circumference, and other indicators. For those with metabolic disorders, personalized plans should be developed under the guidance of a nutritionist. Rapid weight loss in the short term may lead to electrolyte imbalances, menstrual disorders, and other issues. A healthy weight loss rate of 2-4 kilograms per month is recommended.
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