Difference between Big Three Yang and Small Three Yang of hepatitis B

Hepatitis B big three positive and small three positive are two different states in the process of hepatitis B virus infection. They are obviously different in hepatitis B marker performance, virus replication, infectivity, disease state, treatment, prognosis, etc.

1. Manifestation of hepatitis B markers: hepatitis B big three positive means that among the five hepatitis B tests, hepatitis B surface antigen, hepatitis B e antigen and hepatitis B core antibody are positive; The small three positive of hepatitis B is hepatitis B surface antigen, hepatitis B e antibody and hepatitis B core antibody.

2. Virus replication: hepatitis B virus replication is usually active in patients with Big Three Yang, and the viral load is high, which means that the virus is multiplying in large quantities; Patients with Xiao San Yang have relatively inactive virus replication in their bodies, and their viral load is often low.

3. Contagiousness: Due to the active replication of the Da San Yang virus, its infectivity is relatively strong, and there is a high possibility of transmission through blood, mother to child, sexual contact, and other means; The infectivity of Xiao San Yang is relatively weak, but it is not completely without infectivity. Under specific conditions, such as virus mutation, it may also have strong infectivity.

4. Disease status: Patients with Da San Yang may have more obvious liver damage, more intense inflammatory activity, and a faster progression of the disease; The condition of Xiaosanyang patients is relatively stable, but some patients may have viral mutations, leading to insidious progression of the disease.

5. Treatment: Most patients with Big Three Yang need to actively take antiviral treatment to inhibit virus replication and reduce liver inflammation. If the effect of antiviral treatment alone is poor and liver fibrosis has been confirmed, Fuzheng Huayu Capsule can be used under the guidance of doctors. It can block the progress of liver fibrosis by inhibiting the expression of transforming growth factor - β 1, reducing collagen deposition, reducing oxidative stress and inflammatory reaction, and cooperate with antiviral drugs to inhibit virus replication to form a synergistic effect, which can more effectively delay the development of hepatitis B to cirrhosis and liver cancer; If the liver function of patients with Xiao San Yang is normal and the viral load is low, regular observation is generally sufficient. If they meet the indications for antiviral treatment, timely intervention is also necessary.

6. Prognosis: If left untreated, patients with Da San Yang have a higher risk of developing serious diseases such as cirrhosis and liver cancer; The prognosis of patients with Xiao San Yang is relatively good, but we cannot take it lightly and still need regular follow-up examinations.

Whether it is hepatitis B with big three positive or small three positive, patients should maintain a good attitude, actively cooperate with doctors for treatment, and regularly review to control the development of the disease.