Can adapalene gel and retinoic acid be used together

Adapalene gel and retinoic acid are generally not recommended to be used together. They are both topical drugs of retinoic acid, and their combined use may increase the risk of skin irritation. Adapalene belongs to the third generation of retinoids and has relatively low irritability; Retinoic acid is mostly a first generation product, and the mechanism of action of the two is similar. Combined use can easily lead to problems such as dry skin, flaking, and redness. It is recommended to choose one of the uses under the guidance of a doctor, or to stagger the use period.

Adapalene gel mainly improves acne by regulating the differentiation of keratinocytes, and is suitable for mild to moderate inflammatory acne and acne. It has good stability and lower photosensitivity than traditional retinoic acid, making it suitable for nighttime use. When used alone, it is recommended to establish tolerance first. In the initial stage, a thin layer can be applied every other day and combined with moisturizing products to relieve irritation. If the therapeutic effect needs to be enhanced, it can be used alternately with antibacterial ingredients such as benzoyl peroxide in the morning and evening.

Retinoic acid has a direct regulatory effect on epidermal cell proliferation and differentiation, and is commonly used in the treatment of acne, perikeratosis, and photoaging. It is highly irritating and can easily cause damage to the skin barrier. When used in combination with adapalene, it can exacerbate adverse reactions. When combined medication is required in special circumstances, short-term contact therapy should be used under the guidance of a professional physician, or separately applied to different parts, and skin reactions should be strictly monitored.

During the use of retinoids, it is necessary to strengthen sun protection and avoid using them together with alcoholic skincare and exfoliating products. Sensitive muscles can be tested behind the ear first. If there is a persistent burning sensation or edema, it should be stopped immediately. Pregnant and lactating women are prohibited from using such drugs, and children must follow medical advice when using them. If the symptoms of acne do not improve or worsen, seek medical attention promptly to adjust the treatment plan.