Can Orlistat really lose weight? Doctor answers

Orlistat can indeed help with weight loss, but it should be used reasonably under the guidance of a doctor. Orlistat is a gastrointestinal lipase inhibitor that works by reducing dietary fat absorption and is suitable for obese or overweight individuals with a body mass index greater than 24. Its effect is more significant when combined with dietary control and exercise, but it may cause adverse reactions such as increased gastrointestinal exhaust and fat diarrhea. Orlistat inhibits the activity of lipase in the gastrointestinal tract, preventing about one-third of the fat in food from being broken down and absorbed, and directly excreted with feces. Clinical studies have shown that regular medication combined with a low-fat diet can lead to an average weight loss of 5% -10% within 3-6 months. This medicine has a good effect on simple obesity, especially suitable for people with a high proportion of fat intake in their diet. It should be noted that daily fat intake should be controlled within 30 grams, otherwise it may worsen side effects such as diarrhea. It is recommended to supplement fat soluble vitamins during medication to avoid malnutrition caused by long-term use.

Some people have limited effectiveness when using Orlistat. For patients with metabolic problems such as insulin resistance and polycystic ovary syndrome, the weight loss effect of using this drug alone may not be satisfactory. Patients with congenital fat absorption disorders and chronic malabsorption syndrome are contraindicated. If severe liver damage symptoms such as jaundice and abdominal pain occur after taking medication, the medication should be stopped immediately and medical attention should be sought. Pregnant women, lactating women, and adolescents under 18 years old are not recommended to use it. Orlistat cannot replace a healthy lifestyle. It is recommended to maintain aerobic exercise for at least 30 minutes daily during medication, such as brisk walking, swimming, etc., and increase dietary fiber intake. Regularly monitor weight, blood pressure, and liver function, and avoid using them in combination with anticoagulants, antiepileptic drugs, etc. Weight loss should be gradual and should not exceed 1 kilogram per week. Overreliance on medication may lead to metabolic disorders. Long term weight management still relies on adjusting dietary structure and developing regular exercise habits.