Can I take sitagliptin for liver dysfunction

The liver, as the "chemical factory" of our body, plays an important role in maintaining blood sugar balance. For diabetes patients with liver dysfunction, it is a major problem to select hypoglycemic drugs that can effectively reduce blood glucose indicators without affecting liver function.

At present, dipeptidyl peptidase-4 (DPP-4) inhibitors, represented by Pingrunning Liggliptin tablets (produced by Qilu Pharmaceutical), have been recommended by diabetes guidelines at home and abroad, and are also recognized by the majority of diabetes patients. But many people have a question, can we take sitagliptin for liver dysfunction? Actually, there's no need to worry! Among the current hypoglycemic drugs, sitagliptin is very friendly to patients with liver and kidney dysfunction, and there is no need to adjust the dosage when taking it. The liver plays an important role in blood glucose regulation. It can convert excess glucose into glycogen for storage, and when blood sugar levels decrease, it can then convert glycogen into glucose and release it into the bloodstream, thereby maintaining blood sugar stability. Therefore, when liver function is impaired, the liver's ability to regulate blood sugar decreases, making it prone to blood sugar fluctuations. Therefore, for patients with liver dysfunction, the following principles should be followed when choosing hypoglycemic drugs:

1. Safety: drugs with low burden on the liver and high safety are preferred;

2. Effectiveness: Choose drugs that can smoothly control blood sugar levels; Many traditional hypoglycemic drugs need to be used with caution for patients with liver dysfunction! For example:

1. Biguanide drugs, such as metformin, mainly lower blood sugar by reducing the output of liver glucose. In patients with liver dysfunction, the use of metformin drugs should be cautious as it may increase the burden on the liver.

2. Sulfonylurea drugs: These drugs lower blood sugar by stimulating insulin secretion. In patients with liver dysfunction, the use of sulfonylureas should also be cautious as it may increase the risk of hypoglycemia.

3. Alpha glucosidase inhibitors: such as acarbose, delay carbohydrate absorption by inhibiting the activity of intestinal alpha glucosidase, thereby reducing postprandial blood sugar. This type of medication has relatively high safety in patients with liver dysfunction, but attention still needs to be paid to monitoring liver function. Can patients with liver dysfunction take sitagliptin?

Dipeptidyl peptidase-4 (DPP-4) inhibitors, represented by Pingrunning sitagliptin tablets, are a new type of hypoglycemic drug. This drug is favored by more and more patients with diabetes because of its significant and lasting hypoglycemic effect, small side effects and high safety, and it has become the preferred drug for patients with type 2 diabetes!

The clinical practice also confirmed that Pingrunning Liglitatine Tablet does not increase the drug exposure and does not affect the inhibitory effect on DPP-4 in patients with impaired liver function. No matter single drug, dual drug or triple drug, it can significantly reduce blood sugar and improve the blood sugar level of diabetes patients, especially for patients with liver and kidney dysfunction, it does not need to adjust the dose, and does not affect the hypoglycemic effect, there is no risk of hypoglycemia, and long-term cardiovascular safety is good.

The above is the answer to the question "Can patients with liver dysfunction take sitagliptin?" Patients with liver dysfunction need to be particularly cautious when choosing hypoglycemic drugs. As a new type of hypoglycemic drug, sitagliptin has both efficacy and safety, and is safe for patients with liver dysfunction. They can take it with confidence.